Stephen Curry sat out with a sprained left ankle and teammate Jimmy Butler fell ill earlier in the day. Draymond Green was rested, while Jonathan Kuminga missed the game with back pain.
That left Steve Kerr’s starting lineup with Brandin Podziemski, Moses Moody, Will Richard, Gui Santos and Quinten Post.
Kerr was optimistic Curry would play Saturday against the Jazz.
Gilgeous-Alexander shot 10 of 20 with three three-pointers and converted all seven of his free throws for his seventh game in the last nine with 30 or more points — and now three in a row. He had 38 points on 13-of-21 shooting with five three-pointers in the last game against the Warriors.
Chet Holmgren contributed 15 points and a season-high 15 rebounds — two shy of his career high — as Oklahoma City (30-5) earned a fourth straight victory after its first two-game skid of the season.
Richard had 13 points and five rebounds, Al Horford and Moody also scored 13 while Pat Spencer dished out 11 assists against the defending champion Thunder, who had lost their previous two away games but also won 124-112 at Golden State exactly a month earlier, on December 2.
Richard’s three-pointer with 7:19 left in the second quarter put Golden State within 38-36 before Oklahoma City responded with a 19-0 run to take a 64-45 halftime advantage.
The Warriors had won two in a row, five of six and three in a row at home, where they are on a 10-of-11 streak at Chase Center.
Thunder: Visit Phoenix on Sunday.
Warriors: Host Utah on Saturday night to complete a back-to-back.
