The Seattle Seahawks were beaten for the first time this season as Jared Goff played in a 42-29 victory for the Detroit Lions.
Goff completed all 18 of his pass attempts, the most in an NFL game without a miss, including two for touchdowns.
The quarterback also scored his first career receiving touchdown.
“It’s good when the ball doesn’t touch the ground,” Goff told ESPN.
“I wasn’t sure (of the record during the game). I was trying to remember if I had any incomplete passes. I couldn’t really tell, but I knew I had a chance.”
The result leaves both teams at 3-1 for the season.
For the Seahawks, Geno Smith had 395 passing yards and 38 completions on 56 attempts – all career highs – with one touchdown pass and one interception.
The Lions, playing at home at Ford Field, led 21-7 at halftime thanks to two scores from Jahmyr Gibbs and one from David Montgomery.
The Seahawks rallied to get within a score of Detroit, but Goff found Jameson Williams for a 70-yard touchdown to make it 35-20 heading into the final quarter.
Kenneth Walker III had a 21-yard touchdown run to cut the deficit early in the fourth quarter, but Goff picked off Amon-Ra St. Brown in the end zone to seal the victory.
Earlier, it was St. Brown who passed to Goff on a trap play for the quarterback’s touchdown.
The Lions remain second in the NFC North behind the undefeated Minnesota Vikings. Despite the defeat, the Seahawks remain at the top of the NFC West.
The Vikings and Super Bowl champion Kansas City Chiefs are the only NFL teams with a perfect 4-0 record.
In Monday’s other game, the Tennessee Titans beat the Miami Dolphins 31-12 to earn their first win of the season.
Nick Folk kicked five field goals while Tony Pollard and Tyjae Spears rushed for touchdowns at Hard Rock Stadium.
Titans quarterback Will Levis was replaced by Mason Rudolph in the first quarter after he landed heavily on his shoulder and did not return.
Dolphins quarterback Tyler Huntley, replacing the injured Tua Tagovailoa, scored from a late 1-yard run to end the Dolphins’ streak of 10 consecutive quarters without a touchdown.
The Titans remain third in the AFC South ahead of the winless Jacksonville Jaguars. The Dolphins are last in the AFC East at 1-3.